Site activation is the initial set of administrative processes required before a site is ready to recruit patients in a clinical trial. This includes the collection of various site documents (research team signatures, CVs, permissions of hospital authorities), ethics committees/IRB approvals, the negotiation of site contracts and finally initiation visits to research and pharmacy teams. In order to achieve short activation timelines, Sofpromed strategy is based on a deep knowledge of local documentary aspects and institutional policies. Through a global-coverage regional-management approach, Sofpromed ensures agile start-up of international multicenter trials, offering the benefit of less initial operational burden and minimum initiation waiting times for sponsors.